Human microbiome influences rotavirus vaccine response
Thursday, August 9, 2018 - 09:00
in Health & Medicine
In a proof-of-concept study in healthy adult men, scientists in the Netherlands found that microbiome manipulation with antibiotics influenced response to oral rotavirus vaccine. They found higher levels of viral shedding in those receiving antibiotic treatment prior to vaccination compared with controls receiving no antibiotic treatment prior to vaccination. The study demonstrates that altering the bacterial intestinal microbiome can affect a vaccine's immunogenicity.