Gip1 structure places G proteins in lockdown
Monday, November 26, 2018 - 14:50
in Biology & Nature
Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which is important in the detection of various stimuli. Here, researchers found that the protein that regulates activities of G proteins, Gip1, contains a hydrophobic (water-fearing) space, with a unique molecular bonding arrangement that allows interactions with G proteins. These interactions remove G proteins from the cell membrane and sequester G proteins in the cytosol.