Study Decodes Peripheral Neural Networks Defining Itch Sensations

The itch sensation is triggered by two categories of itch-inducing agents: histamine (involving the histamine receptor) and non-histamine (involving a Mas-like G-protein coupled receptor). While the molecular distinction is crucial for developing effective treatments for either itch, it remains unclear as to how the two forms of itches are encoded in the sensory system. A heavily debated school of thought suggests that itch sensation triggered by histamine and non-histamine inducers are triggered by distinct populations of sensory neurons, although such model has never been proven. read more

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