Anti-estrogens may offer protection against lung cancer mortality
Anti-estrogens as therapy for breast cancer may also reduce the risk of death from lung cancer, according to study results presented at the CTRC-AACR San Antonio Breast Cancer Symposium, held here Dec. 9-13, 2009. "We found a reduction in lung cancer mortality among women treated with anti-estrogens for breast cancer. This work builds on previous studies that had suggested estrogens have a role in lung cancer development and progression," said Elisabetta Rapiti, M.D., M.P.H., medical researcher with the Geneva Cancer Registry, University of Geneva, Switzerland.
Rapiti and colleagues evaluated whether anti-estrogen therapy for breast cancer patients reduced their risk of subsequently developing and/or dying from lung cancer.
The study included 6,715 women living in the Geneva canton of Switzerland who were diagnosed with breast cancer, between 1980 and 2003. Forty-six percent of the women received anti-estrogen therapy, primarily tamoxifen.
By the end of the study period, 40 cases of lung cancer developed. There was no difference in the incidence of lung cancer among women with or without anti-estrogens compared with the general population. However, the risk of dying from lung cancer was significantly lower among women who received anti-estrogen therapy.
"Our results are particularly relevant to the research agenda exploring endocrine treatment(s) for lung cancer," said Rapiti. "If prospective studies confirm our results and find that anti-estrogen agents improve lung cancer outcomes, this could have substantial implications for clinical practice."
Phase II clinical trials are currently underway in a number of centers to evaluate the use of anti-hormone therapy as an adjunct to traditional chemotherapy for lung cancer, according to Rapiti.
Source: American Association for Cancer Research
Articles on the same topic
- Novel detection method unmasks circulating breast cancer cellsSat, 12 Dec 2009, 1:24:17 UTC
- Clinical trial advances new approach to re-sensitizing breast cancerFri, 11 Dec 2009, 23:59:12 UTC
- Targeted therapy prolongs life in patients with HER2-positive breast cancerFri, 11 Dec 2009, 18:59:03 UTC
- Disease-free, overall survival inferior for black women with HR-positive breast cancerFri, 11 Dec 2009, 18:27:43 UTC
- A new mouse could help understand how some lung cancer cells evade drug treatmentWed, 9 Dec 2009, 5:24:07 UTC
- Decline in breast cancer: Not just because of hormone therapyTue, 8 Dec 2009, 11:08:30 UTC
- Tiny RNA has big impact on lung cancer tumorsMon, 7 Dec 2009, 12:08:11 UTC
Other sources
- Anti-estrogens may offer protection against lung cancer mortalityfrom Science DailyMon, 14 Dec 2009, 4:14:17 UTC
- Clinical trial advances new approach to re-sensitizing breast cancerfrom PhysorgSun, 13 Dec 2009, 18:56:11 UTC
- Clinical trial advances new approach to re-sensitizing breast cancerfrom Science DailySun, 13 Dec 2009, 5:14:07 UTC
- Novel detection method unmasks circulating breast cancer cellsfrom Science BlogSat, 12 Dec 2009, 1:21:13 UTC
- Anti-estrogens may offer protection against lung cancer mortalityfrom Science BlogFri, 11 Dec 2009, 21:56:31 UTC
- Disease-free, overall survival inferior for black women with HR-positive breast cancerfrom Science BlogFri, 11 Dec 2009, 21:56:27 UTC
- Targeted therapy prolongs life in patients with HER2-positive breast cancerfrom Science BlogFri, 11 Dec 2009, 21:56:11 UTC
- Targeted therapy prolongs life in patients with HER2-positive breast cancerfrom PhysorgFri, 11 Dec 2009, 21:28:06 UTC
- Targeted therapy prolongs life in patients with HER2-positive breast cancerfrom Science DailyFri, 11 Dec 2009, 21:21:13 UTC
- Most Oncologists Feel New Genetic Test for Tamoxifen Sensitivity Not Ready for the Clinicfrom PhysorgFri, 11 Dec 2009, 20:14:52 UTC
- Targeted therapy prolongs life in patients with HER2-positive breast cancerfrom Science BlogFri, 11 Dec 2009, 20:07:16 UTC
- Disease-free, overall survival inferior for black women with HR-positive breast cancerfrom Science BlogFri, 11 Dec 2009, 18:56:28 UTC
- Disease-free, overall survival inferior for black women with HR-positive breast cancerfrom PhysorgFri, 11 Dec 2009, 18:21:53 UTC
- Anti-estrogens may offer protection against lung cancer mortalityfrom PhysorgFri, 11 Dec 2009, 17:35:25 UTC
- Anti-estrogens may offer protection against lung cancer mortalityfrom Science BlogFri, 11 Dec 2009, 17:21:25 UTC
- Decline of hormone therapy decreases breast cancer cases, analysis findsfrom PhysorgWed, 9 Dec 2009, 23:14:17 UTC
- New mouse could help understand how some lung cancer cells evade drug treatmentfrom Science DailyWed, 9 Dec 2009, 15:45:13 UTC
- A new mouse could help understand how some lung cancer cells evade drug treatmentfrom PhysorgWed, 9 Dec 2009, 10:49:14 UTC
- A new mouse could help understand how some lung cancer cells evade drug treatmentfrom Science BlogWed, 9 Dec 2009, 6:07:21 UTC
- Decline in breast cancer: Not just because of hormone therapyfrom PhysorgTue, 8 Dec 2009, 11:07:07 UTC
- Tiny RNA has big impact on lung cancer tumorsfrom Biology News NetMon, 7 Dec 2009, 23:56:37 UTC
- Tiny RNA has big impact on lung cancer tumorsfrom Science DailyMon, 7 Dec 2009, 17:14:30 UTC
- Tiny RNA has big impact on lung cancer tumorsfrom Science BlogMon, 7 Dec 2009, 12:49:16 UTC
- Tiny RNA has big impact on lung cancer tumorsfrom PhysorgMon, 7 Dec 2009, 12:07:06 UTC