Is the Shape of a Genome as Important as Its Content?

Ken-ichi Noma, Ph.D., and Wistar researchers determined the three-dimensional structure of the fission yeast genome, S. pombe. The study is the first to combine microscopy with advanced genomic sequencing techniques, enabling researchers to literally see gene interactions. Applying this technique to the human genome may provide both scientists and physicians a whole new framework from which to better understand genes and disease. The study was published online as a featured article in the journal Nucleic Acids Research.

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