Is transforming growth factor-beta involved in intestinal wound healing?

Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation of cell migration, cell differentiation, extracellular matrix deposition, and immune responses. Since the regulation of migration and differentiation of intestinal fibroblasts is an important mechanism during intestinal wound healing and fibrosis, it is important to investigate the effect of TGF- beta 1 on these processes and on fibronectin (FN) and FN isoform production.

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