New reagents for genomic engineering of mouse models to understand human disease

A new study published in Disease Models and Mechanisms, reports new tools for generating specifically targeted genetic mutations in bacteria, mammalian cells and mice. The new recombinase, Dre, is similar to its predecessor, Cre, but targets unique sites within DNA for recombination. It may be used in combination with currently available methods to produce more complex mouse models to understand disease.

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