Master regulator found for regenerating nerve fibers in live animals

Sunday, October 25, 2009 - 14:21 in Health & Medicine

Researchers at Children's Hospital Boston report that an enzyme known as Mst3b, previously identified in their lab, is essential for regenerating damaged axons (nerve fibers) in a live animal model, in both the peripheral and central nervous systems. Their findings, published online by Nature Neuroscience on October 25, suggest Mst3b - or agents that stimulate it - as a possible means of treating stroke, spinal cord damage and traumatic brain injury. Normally, neurons in the central nervous system (the brain and spinal cord) cannot regenerate injured nerve fibers, limiting people's ability to recover from brain or spinal cord injuries.

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