Study examines interval colorectal cancer despite surveillance colonoscopy

A new study examines the occurrence of interval colorectal cancer despite regular colonoscopy and highlights the importance of close follow-up for patients who have a history of advanced adenomas, which are precancerous polyps. Researchers studied the rate of interval colorectal cancer in patients participating in the Polyp Prevention Trial Continued Follow-up Study and found that nine cases of colorectal cancer were diagnosed over 7,626 person-years of observation for an incidence rate of 1.2 per 1,000 person-years of observation. Of patients in whom colorectal cancer developed, 78 percent had a history of advanced adenoma. The majority of the cancers detected were early stage (78 percent were stage I or II) and therefore highly curable.

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