Constant overlap: Scientists identify molecular machinery that maintains important feature of the spindle

During cell division, microtubules emanating from each of the spindle poles meet and overlap in the spindle's mid zone. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have uncovered the molecular mechanism that determines the extent of this overlap. In a study published today in Cell, they were able to reconstruct such anti-parallel microtubule overlaps in vitro, and identify two proteins which are sufficient to control the formation and size of this important spindle feature.

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