Study suggests earliest brain changes associated with the genetic risk of Alzheimer's disease

What are the earliest brain changes associated with the risk of developing Alzheimer's disease? A scientific report published in the October Journal of Alzheimer's Disease finds reduced activity of an energy-generating enzyme in deceased young adult brain donors who carry a common genetic risk factor for Alzheimer's disease—before the protein changes or microscopic abnormalities commonly associated with the disease and almost five decades before the age at which they might have developed memory and thinking problems.

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