Malfunctioning gene associated with Lou Gehrig's disease leads to nerve-cell death in mice

Tuesday, January 4, 2011 - 17:31 in Health & Medicine

(PhysOrg.com) -- Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) are characterized by protein clumps in brain and spinal-cord cells that include an RNA-binding protein called TDP-43. This protein is the major building block of the lesions formed by these clumps.

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