Save messengers -- modified mRNAs open up new therapeutic possibilities

Defects in the genome are the cause of many diseases. Gene therapy – direct replacement of mutant genes by intact DNA copies – offers a means of correcting such defects. Now a research team based at the Medical Center of the University of Munich, and led by Privatdozent Dr. Carsten Rudolph, has taken a new approach that avoids DNA delivery. The team shows for the first time that chemical modification of mRNAs (the metabolically active molecules derived from genomic DNA that programs protein synthesis) provides a promising alternative to DNA-based procedures.

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