Alzheimer's-like brain changes found in cognitively normal elders with amyloid plaques

Researchers using two brain-imaging technologies have found that apparently normal older individuals with brain deposits of amyloid beta – the primary constituent of the plaques found in the brains of Alzheimer's disease patients – also had changes in brain structure similar to those seen in Alzheimer's patients. Results of the study, which has received early online publication in the Annals of Neurology, may help identify individuals who could be candidates for therapies to prevent the development of dementia.

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