NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis

The natriuretic peptide (NP) receptor type B (NPR-B) gene was expressed in gastric smooth muscles of normal and diabetic rats and the expression was increased in diabetic rats. These results suggest that natriuretic peptide-dependent pGC-cGMP signal is up-regulated and it may contribute to diabetic gastroparesis in STZ-induced diabetic rat.

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