Loss of tumor-suppressor and DNA-maintenance proteins causes tissue demise
Thursday, October 15, 2009 - 15:49
in Health & Medicine
PHILADELPHIA - A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals.