German researchers make significant strides in identifying cause of bacterial infections
Thursday, April 23, 2009 - 08:56
in Biology & Nature
Several bacterial pathogens use toxins to manipulate human host cells, ultimately disturbing cellular signal transduction. Until now, however, scientists have been able to track down only a few of the proteins that interact with bacterial toxins in infected human cells. Now, researchers of the Max Planck Institute of Biochemistry in Martinsried and the Max Delbrueck Centre for Molecular Medicine (MDC) Berlin-Buch in Germany have identified 39 interaction partners of these toxins, using novel technology which allowed them to screen for large numbers of proteins simultaneously (Cell Host and Microbe, Vol. 5, Issue 4, 397-403)...