Human Mdm2: A new molecular link to late-stage metastatic breast cancer

A large proportion of late-stage breast cancers that have spread to other parts of the body (metastatic breast cancers) are characterised by overexpression of the protein Mdm2. Lindsey Mayo and colleagues, at Indiana University School of Medicine, Indianapolis, have now determined what drives this increased Mdm2 expression and found that Mdm2 helps promote cancer cells take on more aggressive characteristics, making it a potential target for drugs to treat late-stage metastatic breast cancer...

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