Defective signalling pathway leads to vascular malformations in the brain

Benign vascular malformations known as cavernomas can occur in many tissues of the body. These abnormalities are characterised by enlarged, instable and unstructured blood vessels. Cavernomas of medical relevance are primarily those of the brain, which develop approximately in one out of two hundred people. In the brain, such growths often remain unnoticed and are typically found by chance in MRI scans. If they grow larger, they often cause unspecific symptoms such as headaches or dizziness. There is a growing danger of cerebral haemorrhage from these vascular growths, which can lead to seizures, neurological failures and even stroke. Therefore, cavernomas causing symptoms are surgically removed from the brain, if possible...

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