Gladstone scientists uncover mechanism for the major genetic risk factor of Alzheimer's disease

Alzheimer's disease (AD) is an extremely complicated disease. Several proteins seem to be involved in its cause and progression. For example, the lipid-transport protein apolipoprotein E4 (apoE4) is the major genetic risk factor for AD, and apoE4 carriers account for 65 % of all Alzheimer's cases, but exactly how apoE4 contributes to the disease is unclear...

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