Apoptotic mechanisms of octreotide on HepG2

Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and is estimated to cause approximately half a million deaths annually. Undoubtedly, the best available treatment for all liver tumours is complete surgical resection. However, the synthetic somatostatin analogue octreotide has been found effective in inhibiting tumour growth in a variety of experimental models. It has been reported that octreotide inhibits the proliferation and induces apoptosis of different HCC cell lines in vitro. The mechanisms of apoptosis induction however are not well understood...

Read the whole article on

More from