Protein That Provides Innate Defense Against HIV Could Lead To New Treatments

The HIV-1 protein Vpu is necessary for the HIV-1 virus to be released from human cells. Scientists have identified CAML as a human cellular protein that blocks the release of HIV-1 viral particles from the membrane of infected cells. The Vpu protein is able to counteract the effects of CAML and allow the release of HIV-1 particles. Understanding how CAML provides an innate defense against HIV and how Vpu counteracts this defense should help scientists develop new treatments.

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