'Disordered' Amino Acids May Really Be There To Provide Wiggle Room For Signaling Protein

Sections of proteins previously considered "disorganized" could actually give proteins more room to flex, at least in the example of NHERF1, a scaffolding protein whose structure is published for the first time. A third of the amino acids in NHERF1 were thought to be intrinsically disorganized, forming no known structures and matching no known evolutionarily-conserved pattern. Instead, the disorganized structure gives the protein the flexibility it needs to function.

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