Stem-cell activators switch function, repress mature cells

New research shows how a crucial step in stem-cell growth and differentiation happens and how a reversal of that step contributes to cancer. It shows that three key proteins first stimulate stem cells to proliferate. Then, as the cells differentiate into their final cell type, these proteins switch function and stop the cells from dividing any more. Because of their central role, the proteins could offer a safe and novel therapeutic target in many cancers.

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