How a tumor suppressor induces senescence and staves off cancer

The retinoblastoma (RB) gene controls a vast and potent tumor suppression pathway, which is disabled in virtually all tumor cells because of mutations in the gene. RB gene mutations are some of the most frequently found in a variety of human cancers. Scientists have now found that a key function of RB in suppressing cancer stems from its ability to induce cellular senescence, a stage of growth arrest in which cells no longer divide.

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