How neuroglobin protects against Alzheimer's
Tuesday, August 3, 2010 - 01:14
in Biology & Nature
The researchers developed predictions from computational modeling and validated them with biological experiments. They found that neuroglobin binds to cytochrome c and prevents it from forming an apoptosome. In Alzheimer's disease, a toxic type of protein accumulates in brain neurons and leads to mitochondrial rupture and cell death. The finding suggests that high neuroglobin levels may buffer neurons against the effect of this protein by preventing apoptosomes from forming.