Age-related macular degeneration: Key mechanism in geographic atrophy identified, 2 possible therapies

Scientists have discovered a deficiency of the Dicer enzyme in retinal cells of patients with geographic atrophy. Further research showed that, in the absence of Dicer, toxic Alu RNA can accumulate, leading to retinal cell death characteristic of geographic atrophy. Two therapeutic modalities targeting these mechanisms have been developed and are headed toward clinical trials.

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