New model for probing antidepressant actions

Friday, February 18, 2011 - 18:30 in Health & Medicine

How antidepressants called selective serotonin reuptake inhibitors (SSRIs) work can be thoroughly explored with a new mouse model developed by neuroscientists. The mice express a serotonin transporter that has been genetically altered so that it does not respond to many SSRIs or cocaine. The new mouse model could also lead to the development of entirely new classes of antidepressant medications.

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