Model organisms? Broadening the biological lexicon to bolster translational research

So-called model organisms have long been at the core of biomedical research, allowing scientists to study the ins and outs of human disorders in non-human subjects. In the ideal, such models accurately recapitulate a human disorder so that, for example, the Parkinson's disease observed in a rat model would be virtually indistinguishable from that in a human patient. The reality, of course, is that rats aren't human, and few models actually faithfully reflect the phenotype of the disease in question. Thus, in the strictest sense of the word, many "models" aren't truly models at all. To developmental biologist, this is no small matter.

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