Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
Monday, April 25, 2011 - 12:30
in Biology & Nature
Researchers have discovered that human proteins with an affinity for dermatan sulfate (DS) have the propensity to become autoantigens. In a companion article, the researchers also found that DS physically interacts with dead cells and that the resulting DS-autoantigen complexes drive autoreactive B-1a cell responses and autoantibody production both in-vitro and in mouse models.