Calcineurin Critical To Normal Heart Function

The enzyme calcineurin is critical to normal development and function of heart cells, and loss of the protein leads to heart problems and death in genetically modified mice, according to researchers at Cincinnati Children's Hospital Medical Center Their new study, published in the Journal of Biological Chemistry, demonstrates that calcineurin in hearts of mice is directly linked to proper cardiac muscle contraction, rhythm and maintenance of heart activity. The near total absence of calcineurin in mice leads to heart arrhythmia, failure and death, according to the research team. read more

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