Sonic Hedgehog Found In Ectoderm Of Mice Embryos

Sonic hedgehog, a gene that plays a crucial rule in the positioning and growth of limbs, fingers and toes, has been found in the ectoderm - the cell layer that gives rise to the skin - in the embryos of developing mice. The gene was previously thought to be exclusively present in the cell layer that builds bone and muscle, called the mesoderm. The discovery, detailed in PNAS, suggests that Sonic hedgehog's role in the growth of appendages is far more complex than originally thought. Developmental biologists may have to rethink established theories about how limbs are patterned in vertebrates — an effort that could provide insight into human birth defects. read more

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