Bringing information into the cell

Researchers have elucidated an important part of a signal pathway that transmits information through the cell membrane into the interior of a cell. This signal pathway is of great significance...

Sooner or Later Your Cousin’s DNA Is Going to Solve a Murder

The Golden State Killer case was just the start. Hundreds of cold cases are hot again thanks to a new genealogy technique. The price may be everyone’s genetic privacy.

Scientists unlock new role for nervous system in regeneration

Biologists at Tufts University have developed a computational model of planarian (flatworm) regeneration that explains how fragments of planaria determine which end should form a tail and which should form...

Study: Americans' beliefs about wildlife management are changing

Abundant and healthy wildlife populations are a cultural and ecological treasure in the United States. Over time, however, the decisions about how agencies manage wildlife have become highly contested: How...

Erratum for the Report "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry" by D. S. Chorev, L. A. Baker, D. Wu, V. Beilsten-Edmands, S. L. Rouse, T. Zeev-Ben-Mordehai, C. Jiko, F. Samsudin, C. Gerle, S. Khalid

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Metabolic health depends on the capacity of adipose tissue progenitor cells to undergo de novo adipogenesis. The cellular hierarchy and mechanisms governing adipocyte progenitor differentiation are incompletely understood. Through single-cell...

Cell competition during reprogramming gives rise to dominant clones

The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have identified molecular networks that reprogram cells to pluripotency,...

Long-term functional maintenance of primary human hepatocytes in vitro

The maintenance of terminally differentiated cells, especially hepatocytes, in vitro has proven challenging. Here we demonstrated the long-term in vitro maintenance of primary human hepatocytes (PHHs) by modulating cell signaling...

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response...

The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

Membrane-integral adenylyl cyclases (ACs) are key enzymes in mammalian heterotrimeric GTP-binding protein (G protein)–dependent signal transduction, which is important in many cellular processes. Signals received by the G protein–coupled receptors...

Mechanism of 5' splice site transfer for human spliceosome activation

The prespliceosome, comprising U1 and U2 small nuclear ribonucleoproteins (snRNPs) bound to the precursor messenger RNA 5' splice site (5'SS) and branch point sequence, associates with the U4/U6.U5 tri-snRNP to form the fully...

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Glutamate-gated AMPA receptors mediate the fast component of excitatory signal transduction at chemical synapses throughout all regions of the mammalian brain. AMPA receptors are tetrameric assemblies composed of four subunits,...

Bringing information into the cell

Researchers at the Paul Scherrer Institute (PSI) have elucidated an important part of a signal pathway that transmits information through the cell membrane into the interior of a cell.

Fishing for cures: New zebrafish model identifies drugs that kill pediatric cancer cells

A new immunodeficient zebrafish model investigators promises to be less expensive, easier to use and to improve personalized therapies for cancers and potentially other diseases. The ability of the model...

Songbird-body changes that allow migration may have human health implications

Songbirds that pack on as much as 50 percent of their body weight before migrating and that sleep very little, exhibit altered immune system and tissue-repair function during the journey,...

Meet Callichimaera perplexa, the platypus of crabs

The crab family just got a bunch of new cousins -- including a 95-million-year-old chimera species that will force scientists to rethink the definition of a crab.

Pole-to-pole study of ocean life identifies nearly 200,000 marine viruses

An international team has conducted the first-ever global survey of the ecological diversity of viruses in the oceans during expeditions aboard a single sailboat. They identified nearly 200,000 marine viral...

Sex and diet affect protein machineries

Scientists have discovered that the collection of proteins in an animal cell -- called the proteome -- is substantially affected by both the animal's sex and its diet. Understanding these...

NFL Draft 2019: Jets, Lions, Dolphins, Seahawks, Rams looking to trade down

The 2019 NFL Draft kicks off Thursday in Nashville and several teams are looking to trade down or out of the first round.

Watch: Potato sculpture converted into hotel in Idaho

A giant potato sculpture built to promote Idaho's spud farmers is being converted into the Big Idaho Potato Hotel, a single-room accommodation.

New key stages discovered in how plants prepare to make sex cells for reproduction

Scientists have built a detailed timeline of the gene activity leading up to meiosis in corn, a finding with potential implications for plant breeding as well as sexually reproductive organisms...

Gestures and visual animations reveal cognitive origins of linguistic meaning

Gestures and visual animations can help reveal the cognitive origins of meaning, indicating that our minds can assign a linguistic structure to new informational content 'on the fly' -- even...

Marines to field enhanced handheld targeting system later this year

The U.S. Marine Corps plans later this year to integrate new technologies into the existing Common Laser Range Finder-Integrated Capability handheld GPS targeting system.

Sea ice decline triggers breeding failure at second largest emperor penguin colony

The world's second largest emperor penguin colony is no more after residents of the Halley Bay colony failed to raise chicks for three straight years.

Pole-to-pole study of ocean life identifies nearly 200,000 marine viruses

An international team has conducted the first-ever global survey of the ecological diversity of viruses in the oceans during expeditions aboard a single sailboat, the Tara. They identified nearly 200,000...

Chemical engineers replicate feed, fight and flight responses in catalytic chemical reactions

Collaboration and competition are basic instincts among biological species, from the simplest single-celled organisms to reptiles, fish and primates, as well as humans. This dynamic behavior—the result of millions of...

Gestures and visual animations reveal cognitive origins of linguistic meaning

Gestures and visual animations can help reveal the cognitive origins of meaning, indicating that our minds can assign a linguistic structure to new informational content "on the fly"—even if it...

Songbird-body changes that allow migration may have human health implications

Songbirds that pack on as much as 50 percent of their body weight before migrating and that sleep very little, exhibit altered immune system and tissue-repair function during the journey,...