hefA plays an important role in multidrug resistance of Helicobacter pylori

Three RND efflux systems had been identified in H pylori, namely hefABC, hefDEF, and hefGHI, each of which consisted of a translocase, an accessory protein. But the contribution of efflux proteins to antibiotic resistance is not well established. 27 putative translocases also had been identified in the H pylori 26695 genome, but only four putative H pylori OEPs or TolC homologs were identified. While they could not quantitate the operons expression levels of the efflux systems in multidrug resistance strains of H pylori.

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