Bone's material flaws lead to disease: Tiny rifts create fragility of brittle bone disease

(PhysOrg.com) -- The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon.

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