Molecular architecture of key NMDA receptor subunit revealed

Tuesday, April 26, 2011 - 10:30 in Biology & Nature

Structural biologists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at Emory University have determined the molecular structure of a key portion, or subunit, of a receptor type commonly expressed in brain cells. The receptor is one of several NMDA (N-methyl-D-aspartate) receptor variants, and the subunit in question is that which specifically binds with excitatory neurotransmitters, most notably glutamate, the brain's most prevalent excitatory neurotransmitter.

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