Scientists identify broad and potent HIV antibodies that mimic CD4 binding

In a finding that may be good news for scientists developing HIV vaccines and therapies, a team of researchers at The Rockefeller University and the Howard Hughes Medical Institute have found a way to investigate the broadly neutralizing antibody response against the CD4 binding site of HIV on a monoclonal level. This led to the identification and characterization of several “highly active anti-CD4 binding site antibodies” (HAADs) and their expanded B cell families.

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