A step closer to understanding, averting drug resistance
Tuesday, January 31, 2012 - 09:02
in Physics & Chemistry
(Medical Xpress) -- The multidrug transporter EmrE functions as an asymmetric antiparallel dimer (molecule with two subunits). Drug (blue) transport from the inside to the outside of the cell membrane is accomplished by exchange between inward (left) and outward (right) facing conformations in exchange with two protons (green), directly visualized by nuclear magnetic resonance spectroscopy.