Water plays a key role in the co-crystallization of active pharmaceutical ingredients

There is much more to drug development than simply identifying a potent active pharmaceutical ingredient (API). Scientists must ensure that the API can tolerate the production process, remain stable during storage and distribution, and behave appropriately inside the patient’s body after administration. One emerging technique for improving the performance of APIs with non-ideal physicochemical properties is to co-crystallize them with a second compound that modulates their behavior. Srinivasulu Aitipamula and co-workers at the A*STAR Institute of Chemical and Engineering Sciences have now developed a novel route for preparing such co-crystals.

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