Drug side effects examined
Yellow vision, pseudo-pulmonary obstruction, involuntary body movements, respiratory paralysis. These are some of the 1,600 known side effects (SEs) produced by drugs. Adverse effects are one of the main causes of hospital admission in the west. These effects are difficult to predict, and in practice specific assays are required to test the safety of agents in pre-clinical phases, thus these effects are often not discovered until the drug has been launched. A study published by scientists at the Institute for Research in Biomedicine (IRB Barcelona) seeks to fill this information gap. The objective of the study is to shed light on the molecular bases of SEs and provide medical chemists with the tools to design safer drugs and to predict their effects. The study collects and proposes molecular hypotheses for 1,162 side effects. This information, which is about to be tested experimentally, is now available to the scientific community through...