Scientists cut through data noise of high-throughput DNA sequencing with mathematical technique
Monday, June 17, 2013 - 06:30
in Biology & Nature
(Phys.org) —Scientists at A*STAR's Genome Institute of Singapore (GIS) have developed a revolutionary method to quickly cut through noise and generate a unified and simplified analysis of high-throughput biological data from, for example, patient samples. The technique, known as a pre-whitening matched filter, is well known in electrical engineering and widely used in cell phones and radar. This is the first time, however, computational scientists, led by Dr Shyam Prabhakar, Associate Director, Integrated Genomics, GIS, have adapted it to the analysis of high-throughput DNA sequencing data, with surprisingly accurate results. The development was recently published in the prestigious journal, Nature Biotechnology.