Structural insights into the inner workings of a viral nanomachine

Researchers at the Virginia Tech Carilion Research Institute (VTCRI) are using new nanoscale imaging approaches to shed light on the dynamic activities of rotaviruses, important pathogens that cause life-threatening diarrhea in young children. Once a rotavirus enters a host cell, it sheds its outermost protein layer, leaving behind a double-layered particle (DLP). These DLPs are the form of the virus that produces messenger RNA molecules, which are critical for launching the infection.

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