Gip1 structure places G proteins in lockdown
Monday, November 26, 2018 - 09:00
in Biology & Nature
Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical signals. G protein functions are regulated by interactions with Gip1, a protein that sequesters G proteins to block signaling processes. Many studies have attempted to understand the mechanism for this interaction between G proteins and Gip1; none have provided a clear explanation, until now.