New tricks of TALEs: Discovery of a new principle of gene regulation by molecular displacement

Transcription activator-like effector (TALE) proteins can be designed to bind to almost any selected DNA. Researchers now report that a TALE can displace another TALE protein from DNA in a highly polarized way – it can displace a TALE protein binding to DNA adjacent to its right but not its left side. This unusual property of TALEs has been used to increase the precision of gene expression regulation, to design logic circuits in mammalian cells, and to prevent CRISPR cleavage at non-desired DNA sites.

Read the whole article on Physorg

More from Physorg