Scientists lay foundation for single-cell level understanding of DNA replication
Monday, February 25, 2019 - 11:20
in Biology & Nature
A research team has established a novel method to scrutinize DNA replication in individual cells. This method allowed them to obtain a detailed genome-wide view of replicated and unreplicated sequence distribution in each cell. They also succeeded in discriminating paternally and maternally derived homologous chromosomes in each cell by utilizing single-nucleotide variations between parents, making it possible to successfully visualize how each chromosome in the cell is replicated.