Missing link explains mRNA delivery in brain cells
Friday, June 2, 2023 - 09:13
in Biology & Nature
Brain cells manufacture proteins in every corner, including their long branches. Neurons missing this ability cause severe neurological disorders like disability and epilepsy. The groups of Marino Zerial, Max Planck Institute (MPI) of Molecular Cell Biology and Genetics in Dresden, and Stefan Raunser, MPI of Molecular Physiology in Dortmund, together with colleagues from the MPI for Brain Research in Frankfurt am Main and the MPI for Biophysical Chemistry in Göttingen have discovered a new delivery mechanism that brings messenger RNA (mRNA), the proteins' blueprint, to the point of need in neurons.