Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein
Tuesday, September 8, 2009 - 05:56
in Biology & Nature
Scientists at Fox Chase Cancer Centre have discovered a unique method of attack that may be used to inhibit signalling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, targets the enzyme's regulatory domain, mimicking how enzymes are naturally regulated within cells...