How loss of key protein promotes aggressive form of leukemia
Sunday, July 4, 2010 - 05:28
in Biology & Nature
New research illuminates in fine detail one of the genetic paths that leads to a particularly aggressive form of leukemia. A team discovered a new tumor-suppressing function of p53, distinct, for instance, from apoptosis, and somewhat related to senescence. They showed that it has the ability to reinforce cell-fate and differentiation programs. In AML, p53 loss leads to cancer by disabling this reinforcement.