Researchers discover trigger to early, effective antibody response

Researchers have discovered a trigger that induces B cells to produce effective, long-lived antibodies early in the immune response. A molecule that binds toll-like receptors doubles the early antibody response, and shifts it to a more effective, IgG form. The findings support the emerging concept of "bridge immunity," which links the innate and adaptive arms of the immune response. They may also lead to the development of better vaccines.

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