Immunity: A secret to making macrophages
Thursday, July 18, 2013 - 16:30
in Biology & Nature
Biologists have worked out the details of a mechanism that leads undifferentiated blood stem cells to become macrophages -- immune cells that attack bacteria and other foreign pathogens. The process involves an unexpected cycle in which cell division slows, leading to an increased accumulation of a particular regulatory protein that in turn slows cell division further. The finding provides new insight into how stem cells are guided to generate one cell type as opposed to another.